Significance of delta agent infection in chronic hepatitis B virus infection: a study in British carriers.

نویسندگان

  • I V Weller
  • P Karayiannis
  • A S Lok
  • L Montano
  • M Bamber
  • H C Thomas
  • S Sherlock
چکیده

Delta antigen (delta) is a transmissible agent requiring hepatitis B virus (HBV) for its replication. Antibody to delta (anti-delta) was present in nine of 71 (13%) British HBV carriers: six were intravenous drug abusers and two were haemophiliacs. Anti-delta was negative in 30 HBsAg positive homosexuals. Cirrhosis was common in patients with anti-delta and those with anti-delta positive cirrhosis were significantly younger than those with anti-delta negative cirrhosis. In British HBV carriers delta infection is associated with intravenous drug abuse and haemophilia and perhaps a more rapid progression of chronic liver disease.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Prevalence of hepatitis delta virus infection in various groups with HBVinfection in Tehran, Imam Khomeini Hospital (2005-2006)

    Abstract   Background: Hepatitis B virus infection is an important cause of liver morbidity and   mortality worldwide. HDV changes the natural course of HBV. The prevalence of HDV infection wasn’t determined in the various groups of HBV infection (carriers, acute hepatitis, chronic hepatitis, cirrhosis and HCC) in Iran. We aimed to research the prevalence of hepatitis D virus infection in v...

متن کامل

Molecular detection of hepatitis delta virus in blood donors with RT-PCR

Abstract Background and Objective: Hepatitis delta virus is an imperfect virus with RNA and its activity depends on the presence of hepatitis B virus. This virus can lead to acute and chronic diseases in the liver. This study aimed to detect the hepatitis delta virus in blood donors with positive Hepatitis B Surface Antigens (HBsAg). Material and Methods: In this Study, 350 serum sa...

متن کامل

Clinical Impact and Frequency of Hepatitis D Virus Infection in HBsAg Positive Patients in a Southern Province of Iran (Kerman)

Background and Aims: Hepatitis D virus (HDV) can infect human population either as a superinfection or concurrent hepatitis B virus (HBV) infection. It is expected that presence of HDV infection is more prevalent in endemic HBV areas. Overall 5% of Iranian general populations are chronic HBV carriers. The aim of this study was to determine the seroprevalence of HDV and its clinical impact in ...

متن کامل

Determination of Hepatitis Delta Virus Genotype among HBV Carriers in Southwest of Iran

Background and Aims: HDV is a defective satellite virus and classified in genus Deltavirus. Its disease is related and limited to HBV-infected patients. Acute infection of delta agent occurs in two different patterns simultaneous infection with both HBV & HDV or super infection of chronically HBV infected patients that lead to more sever type of hepatitis. According to genetic diversity of geno...

متن کامل

Intra-familial Transmission of Hepatitis B Virus Infection in Arak, Central Iran

Background: The household transmission of hepatitis B virus (HBV) is a major health problem. High incidence of HBV infection is observed within the household contacts of HBV carriers. We aimed to evaluate serological markers of hepatitis B infection among family members of HBV carriers in Arak, central Iran. Methods<stron...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Gut

دوره 24 11  شماره 

صفحات  -

تاریخ انتشار 1983